Look Into the Eyes Of the Sun

Holy crap! Cheeseburgers ate your memory!

LONDON (Reuters) - Mice fed junk food for nine months showed signs of developing the abnormal brain tangles strongly associated with Alzheimer's disease, a Swedish researcher said on Friday.

The findings, which come from a series of published papers by a researcher at Sweden's Karolinska Institutet, show how a diet rich in fat, sugar and cholesterol could increase the risk of the most common type of dementia.

If this study was commissioned by the Lutefisk Growers Association to get us to eat that mess, they can just forget it.

"On examining the brains of these mice, we found a chemical change not unlike that found in the Alzheimer brain," Susanne Akterin, a researcher at the Karolinska Institutet's Alzheimer's Disease Research Center, who led the study, said in a statement.

"We now suspect that a high intake of fat and cholesterol in combination with genetic factors ... can adversely affect several brain substances, which can be a contributory factor in the development of Alzheimer's."

Alzheimer's disease is incurable and is the most common form of dementia among older people. It affects the regions of the brain involving thought, memory and language.

If only I knew what we were talking about. Hey, does anyone smell french fries?

While the most advanced drugs have focused on removing clumps of beta amyloid protein that forms plaques in the brain, researchers are also now looking at therapies to address the toxic tangles caused by an abnormal build-up of the protein tau.

In her research, Akterin focused on a gene variant called apoE4, found in 15 to 20 percent of people and which is a known risk factor for Alzheimer's. The gene is involved in the transport of cholesterol.

Bacon macrames brains? That lends new meaning to the phrase, "I'm feeling crafty."

She studied mice genetically engineered to mimic the effect of the variant gene in humans, and which were fed a diet rich in fat, sugar and cholesterol for nine months - meals representing the nutritional content of fast food.

...After which the mice guest-judged on Iron Chef America.

These mice showed chemical changes in their brains, indicating an abnormal build-up of the protein tau as well as signs that cholesterol in food reduced levels of another protein called Arc involved in memory storage, Akterin said.

"All in all, the results give some indication of how Alzheimer's can be prevented, but more research in this field needs to be done before proper advice can be passed on to the general public," she said.

The report concluded: Subsequently, the mice demanded fois gras but immediately forgot and locked themselves in the bathroom.

Fortunately, grocery stores now sell really good veggie and lentil burgers, to improve your recollection.